Course Syllabus
Titolo
I PRINCIPI DEL 3RS NEGLI STUDI BIOMEDICI
Docente(i)
GABRIELLA NICOLINI
PARIDE MANTECCA
LUCA CRIPPA
LAURA ANTOLINI
DAVIDE BALLABIO
FERDINANDO CHIARADONNA
SILVIA KIRSTEN NICOLIS
Lingua
Inglese
Breve descrizione
Il corso si propone di introdurre lo studente ai principi delle 3R (Replacement, Reduction & Refinement) negli studi biomedici e di fornire conoscenze di base e applicate sui modelli sperimentali e sugli strumenti da utilizzare nella ricerca sperimentale. Il corso si articolerà in 6 seminari:
-The 3R principles in the legislation regarding the animal experimentation: the European directive 2010/63 and the Italian DL 26/14. (Dott. Crippa)
-Statistical methods applied to the determination of the study dimension in lab experiments: theoretical and practical aspects (free software G-power). (Prof.ssa Antolini)
-Development of QSAR in silico models for the studies on the relationship between structure and molecular properties. (Prof. Ballabio)
-In vitro modeling of complex diseases: 2D and 3D cell systems to dissect cancer biology and to improve translational research (Prof. Ferdinando Chiaradonna)
- Genetic manipulation of in vitro cultured glioma stem cells identifies genes interfering with cell proliferation, that have effective tumor suppressor activity in vivo (Prof.ssa Silvia Kirtsen Nicolis)
-Vertebrate experimental models alternative to mammals: the use of zebrafish and Xenopus laevis in developmental biology and toxicology (Prof. Mantecca)
CFU / Ore
12
Periodo di erogazione
Maggio-Giugno
Title
THE PRINCIPLES OF 3RS IN BIOMEDICAL STUDIES
Teacher(s)
GABRIELLA NICOLINI
PARIDE MANTECCA
LUCA CRIPPA
LAURA ANTOLINI
DAVIDE BALLABIO
FERDINANDO CHIARADONNA
SILVIA KIRSTEN NICOLIS
Language
English
Short description
The course is aimed at introducing the student to the 3R principles (Replacement, Reduction & Refinement) in the biomedical studies and to provide basic and applied knowledge on the experimental models and instruments to be applied in the experimental research. The course will consist of 6 seminars:
-The 3R principles in the legislation regarding the animal experimentation: the European directive 2010/63 and the Italian DL 26/14. (Dott. Crippa)
-Statistical methods applied to the determination of the study dimension in lab experiments: theoretical and practical aspects (free software G-power). (Prof.ssa Antolini)
-Development of QSAR in silico models for the studies on the relationship between structure and molecular properties. (Prof. Ballabio)
-In vitro modeling of complex diseases: 2D and 3D cell systems to dissect cancer biology and to improve translational research (Prof. Ferdinando Chiaradonna)
- Genetic manipulation of in vitro cultured glioma stem cells identifies genes interfering with cell proliferation, that have effective tumor suppressor activity in vivo (Prof.ssa Silvia Kirtsen Nicolis)
-Vertebrate experimental models alternative to mammals: the use of zebrafish and Xenopus laevis in developmental biology and toxicology (Prof. Mantecca)
CFU / Hours
12
Teaching period
May-June