Classification of radiopharmaceuticals with respect to: 1) preparation/production methods (ready-for-use industrially produced radiopharmaceuticals; Kits; extemporaneous preparations), 2) clinical use regulatory aspects: marketing authorization, preparations according to pharmacopoeia, off-label use; 3) clinical applications: diagnostic or therapeutic. Pharmacological bases of the main radiopharmaceuticals used in diagnostics and therapy. Reading of the Summary of Product Characteristics (SmPC) approved by AIFA with particular reference to the specific paragraphs for radiopharmaceuticals (clinical indications, adverse events, methods of use, contraindications, precautions for use, evaluation of in vitro stability, dosimetry. Notes to radionuclide, radiochemical quality controls and biological purity of radiopharmaceuticals and environmental and procedural requirements of a radiopharmacy.