Course Syllabus
Aims
To understand the biochemical pathways underlying the CNS metabolism under physiological conditions. To understand how derangement of metabolism can affect CNS functions. The course will focus on the biochemical and metabolic changes occurring in pathological conditions.
Contents
Metabolism of CNS (saccharides, proteins amino acids, lipids). Biochemistry of the blood-brain barrier. Metabolic changes in pathological conditions. Nutritional aspects.
Detailed program
Metabolism of CNS (saccharides, proteins amino acids, lipids) in physiological conditions. Biochemistry of the blood-brain barrier. Metabolic changes in neurodegenerative diseases. Metabolic changes in brain tumours. Metabolic changes in ischemia-reperfusion injury. Nutritional aspects.
Prerequisites
Basic knowledge of biochemistry, biology and chemistry.
Teaching form
Frontal lectures that require the active participation of students who will be involved in the subject by proposing group work, calculations and discussion of problems related to the change of body metabolism in different conditions. The frontal lessons will take place remotely in asynchronous mode with some videoconferencing events (webex) if COVID19 emergency will persist. The calendar will be available on the elearning platform.
Textbook and teaching resource
Biochemistry with clinical cases . T. Devlin; Biochemistry, Berg et al.
Scientific papers.
Semester
second semester.
Assessment method
Written exam: 10 multiple-choice questions together with the other modules of the NVT.
The exam will be in presence or remotely via web on the base of COVID-19 emergency situation.
The questions proposed in the written exam will be constructed in such a way as to induce the student to biochemical-clinical reasoning, to understand the units of measurement and to be able to evaluate the skills and competences acquired according to the objectives of the course.
Office hours
on appointment to francesca.re1@unimib.it