Course Syllabus
Sustainable Development Goals
Aims
Main aim of the course is to provide students with the pharmacology of major endocrine- and nephro-pathologies. A general description of main hormones and drugs modulating hypothalamic and pituitary activity, thyroid, adrenal glands and gonadal function, affecting bone mineral homeostasis, together with information on drugs acting at the lower urinary tract will be given. Mechanism of action, therapeutic properties, drug interactions, and side effects will also be presented.
Contents
Main classes of drugs, mechanisms of action, drug interactions and precautions.
Detailed program
Hypothalamic and pituitary hormones (somatotropin and growth hormone antagonists, gonadotropin, gonadotropin-releasing hormone analogs and antagonists, prolactin, oxytocin and oxytocin antagonists, vasopressin and vasopressin antagonists.
Thyroid and antithyroid drugs (thyroid hormones and antithyroid agents, management of hypothyroidism and hyperthyroidism).
Adrenocorticosteroids and adrenocortical antagonists (hydrocortisone and synthetic corticosteroids, mineralocorticoids, adrenal androgens, antagonists of glucocorticoids and mineralocorticoids).
Gonadal drugs (estrogens, progestins and other ovarian hormones, hormonal contraception, estrogen and progesterone inhibitors and antagonists, androgens and anabolic steroids, androgen suppression and antiandrogens).
Agents that affect bone mineral homeostasis (parathyroid hormone, vitamin D, FGF23, calcitonin, glucocorticoids, estrogens, bisphosphonates, denosumab, calcimimetics, fluoride, therapy of hypercalcemia and hypophosphatemia).
Drugs for diseases of the lower urinary tract.
Teaching form
5 frontal lessons
Textbook and teaching resource
Bertram G. Katzung “Basic and clinical pharmacology” 14th Edition. LANGE
Goodman & Gilman “The Pharmacological Basis of Therapeutics” 13th Edition, Laurence L. Brunton, Randa Hilal-Dandan, Björn C. Knollmann. McGraw-Hill Education
Rang & Dale “Pharmacology” 14th Edition, Elsevier.
Scientific literature
Semester
Second Semester
Assessment method
As for the vertical track (multiple choice test and oral examination).
Office hours
On appointment (write to: laura.musazzi@unimib.it)
