Course Syllabus
Obiettivi
Descrivere l’eziologia, l’epidemiologia, il quadro clinico e la storia naturale delle principali malattie infettive e sindromi infettive.
Sapere indicare il corretto approccio diagnostico per ogni malattia o sindrome.
Conoscere i principi di terapia antibiotica per le principali malattie infettive.
Conoscere le misure di prevenzione per le principali malattie infettive.
Contenuti sintetici
Principi di epidemiologia, diagnosi, trattamento e prevenzione delle malattie infettive. Diagnosi differenziale e gestione delle sindromi cliniche associate a infezioni. Terapia antibiotica.
Programma esteso
- Infezioni sistemiche
• Sepsi e shock settico
• Febbre tifoide
• Brucellosi
• Malattie di Lyme
• Rickettsiosi
• Infezioni virali sistemiche (EBV , CMV)
• COVID-19 e infezioni emergenti - Infezioni del sistema nervoso centrale
• Meningiti
• Encefaliti ed encefalo mieliti
• Ascesso cerebrale ed empiema subdurale - Infezioni dell’apparato respiratorio
• Infezioni delle alte vie respiratorie
• Polmoniti (incluse polmoniti acquisite in comunità CAP, polmoniti acquisite in ospedale HAP e polmoniti da ventilazione assistita VAP)
• Influenza
• Tubercolosi - Infezioni del sistema cardiovascolare
• Endocarditi infettive
• Miocarditi e pericarditi infettive
• Infezioni catetere correlate - Infezioni dell’apparato digerente
• Diarrea infettiva e gastroenterite
• Diarrea associata a terapia antibiotica e infezione da Clostridium difficile
• Infezioni intra-addominali (inclusa appendicite, colecistite e peritonite) - Malattie tropicali
• Malaria
• Schistosomiasi
• Arbovirosi tropicali (Febbre gialla, dengue, chikungunya, West Nile virus) - Infezioni dell’apparato tegumentario
• Cellulite
• Erisipela
• Gangrena gassosa
• Fascite necrotizzante
-Infezioni muscoloscheletriche
• Artriti settiche primitive e su mezzi di sintesi
• Osteomieliti primitive e su mezzi di sintesi
• Spondilodisciti - Infezione da HIV
• Epidemiologia
• Patogenesi
• Storia naturale dell’infezione
• Principali manifestazioni opportunistiche
• Principi di terapia antiretrovirale
• Trasmissione verticale
• Profilassi pre e post esposizione - Infezioni delle vie urinarie
• Cistite
• Pielonefrite
• Prostatite
-Infezioni sessualmente trasmesse
• Introduzione a epidemiologia e prevenzione
• Sifilide
• Gonorrea
• Chlamydia e malattia infiammatoria pelvica (PID)
• Trichomonas
-Argomenti che verranno discussi nel “Oncohematological Track”
• Vaccinzioni nell’ospite immunocompromesso
• Infezioni nell’ospite immunocompromesso (inclusa neutropenia febbrile)
-Argomenti che verranno discussi nel “Woman and Child Track”
• Infezioni in gravidanza
-Argomenti che verranno discussi nel “Digestive System Track”
- Epatiti virali
Prerequisiti
Corsi di introduzione previsti dal corso di laurea
Modalità didattica
Lezioni frontali con aiuto audio-visivo e discussione in classe, discussione di casi clinici
Materiale didattico
Frederick Southwic – Infectious Diseases. A clinical short course. Mc Graw Hill.
Fourth edition Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2) 20th Edition
Uptodate https://www-uptodate-com.unimib.idm.oclc.org/contents/search
Periodo di erogazione dell'insegnamento
secondo semestre
Modalità di verifica del profitto e valutazione
Esame orale con domande aperte
Orario di ricevimento
Contattare il docente via e-mail
· Prof. Bonfanti Paolo: segreteria.malattieinfettive@irccs-sangerardo.it
· Prof. Puoti Massimo: massimo.puoti@unimib.it
· Prof.ssa Venturelli Serena: sventurelli@asst-pg23.it
Sustainable Development Goals
Aims
By the end of the course, the student will be able to:
• Describe the etiology, the epidemiology (including the route of transmission), the clinical picture, and the natural course of the principal infectious diseases and infective syndromes;
• Integrate such knowledge with the choice of the appropriate diagnostic path for each disease or syndrome (including anamnesis, identification of relevant symptoms and signs, laboratory assessment, radiological tests, diagnosis of complication, and differential diagnosis);
• Describe the therapeutic and preventive measures for the principal infectious diseases and infective syndromes;
• Know the fundamentals of antimicrobial chemotherapy for the most important infectious diseases.
• Analysing and evaluating the onset and symptoms of Infectious Diseases, highlighting how for the same disease, different problems can occur in men and women
Contents
Principles of epidemiology, diagnosis, treatment and prevention of Infectious Diseases.
Differential diagnosis and management of clinical syndromes related to infections ( Systemic infections, Sepsis, Infections of Cardiovascular System, Bone and Joint infections, Skin and Soft tissue infections, Sexually Transmitted Infections,Respiratory tract and Digestive tract infections, Intra Abdominal Infections)
Management of antimicrobial therapy
Detailed program
- Systemic Infectious Diseases
• Sepsis and septic shock
• Typhoid fever and brucellosis
• Lyme disease
• Rickettsial diseases
• Systemic Viral Infections (EBV, CMV)
• COVID-19 and other emerging infectious diseases
-Central Nervous System Infections
• Meningitis
• Encephalitis and myelitis
• Brain abscesses, epidural abscesses - Respiratory Infections
• Upper respiratory tract infections
• Lower respiratory tract infections (including basic concepts on Community Acquired Pneumonia, Health
• Care Associated Pneumonia, Ventilator Associated Pneumonia)
• Influenza
• Tuberculosis (including Latent Tuberculosis and basic notions on extra-pulmonary tuberculosis) - Cardiovascular Infections
• Infective endocarditis (including Cardiovascular Implantable Electronic Devices Infections)
• Catheter-related infections
• Myocarditis and infectious pericarditis (basic notions) - Gastrointestinal and Hepatobiliary Infections*
• Infectious diarrhea & gastroenteritis
• Antibiotic-associated diarrhea and Clostridium difficile infection
• Intra-abdominal infections (including appendicitis, colecystitis, peritonitis)
*Note: viral hepatitis and Helicobacter pylori are discussed in the gastroenterology course. - Tropical Diseases & Parasitic Infections
• Malaria
• Schistosomiasis
• Arbovirosis (Yellow Fever, Dengue, Chikungunya, West Nile Virus) - Skin and Soft Tissues InfectionsCellulitis
• Erysipelas
• Gangrene
• Necrotizing fascitis - Musculoskeletal Infections
• Spondylodiscitis
• Osteomyelitis
• Arthritis (including prosthetic joint infections) - HIV disease
• Epidemiology
• Pathogenesis
• Natural history & main opportunisms
• Principles of antiretroviral therapy
• Vertical transmission
• Pre and post-exposure prophylaxis - Urinary Tract infections
• Cystitis
• Pyelonephritis
• Prostatitis - Sexually Transmitted Diseases
• A general introduction to epidemiology and prevention
• Syphilis
• Gonorrhea
• Nongonococcal urethritis
• Pelvic inflammatory disease (PID)
• Trichomoniasis - Endemic and non endemic mycoses
• Candida species
• Aspergillus species
• Other Yeasts and moulds infections
• Criptococcus, Histoplasmosa, Coccidiodes species , Blastomyces
• Pneumocystis species
-Topics which will be discussed withing the Oncohematological Track
• Vaccinations in the immunocompromised host
• Infections in the immunocompromised host (including febrile neutropenia and infections in asplenic patients)
-Topics which will be discussed withing the Woman and Child Track
• Infections in pregnancy
• Vertically Transmitted Infections
-Topics which will be discussed withing the Digestive System Track - Viral Hepatitis
Prerequisites
Knowledge of the introductory courses indicated in the degree course regulations
Teaching form
Frontal lessons with audio-visual aids and open discussion in the classroom, clinical case discussions.
Textbook and teaching resource
Frederick Southwic – Infectious Diseases. A clinical short course. Mc Graw Hill. Fourth edition
Harrison's Principles of Internal Medicine, Twentieth Edition (Vol.1 & Vol.2) 20th Edition
Uptodate https://www-uptodate-com.unimib.idm.oclc.org/contents/search
Semester
second term
Assessment method
Final oral examination with open questions to assess general knowledge on infectious diseases
Office hours
To get an appointment, please contact the teachers by e-mail:
· prof. Bonfanti Paolo: segreteria.malattieinfettive@irccs-sangerardo.it
· prof. Puoti Massimo: massimo.puoti@unimib.it
· prof. Venturelli Serena: sventurelli@asst-pg23.it
