The course aims to provide a solid scientific and technological foundation in drug delivery, along with a critical analysis of the advantages and limitations of current technologies. It will explore the role of physiological barriers and the principles of pharmacokinetics and pharmacodynamics. The main drug administration routes (oral, parenteral, transdermal, inhalation) and traditional formulations, such as tablets and injections, will be discussed, progressing to innovative technologies like controlled-release systems and nanoparticles. Special attention will be given to nanotechnologies applied to drug delivery, selective targeting strategies, and clinical applications of advanced therapies, including approved nanotechnology-based drugs. To encourage critical engagement with the topics presented, the course will conclude with an interactive, student-led session focused on the presentation and discussion of a case study.